*1. Aden U, Bona E, Hagberg H, Fredholm BB: Changes in c-fos mRNA in the neonatal rat brain following hypoxic ischemia. Neuroscience Letters 180:91-95, 1994

*2. Ames A, Wright RL, Kowada M, Thurston JM, Majno G: Cerebral ischemia. II. The no-reflow phenomenon. Amer J Pathol 52:437-453, 1968

3. Anderson RV, Siegman MG, Balaban RS, Ceckler TL, Swain JA: Hyperglycemia increases cerebral intracellular acidosis during circulatory arrest. Ann Thorac Surg 54:1126-1130, 1992

*4. Ashwal S, Cole DJ, Osborne TN, Pearce WJ: Dual effects of L-NAME during transient focal cerebral ischemia in spontaneously hypertensive rats. Am J Physiol 267:H276-H284, 1994

5. Astrup J: Energy-requiring functions in the ischemic brain. Their critical supply and possible inhibition in protective therapy. J Neurosurg 56:482-497, 1982

*6. Baethmann A, Maier-Hauff K, Kempski O, Unterberg A, Wahl M, Schurer L: Mediators of brain edema and secondary brain damage (review). Crit Care Med 16:972-978, 1988

7. Bell BA, Symon L, Branston NM: CBF and time thresholds for the formation of ischemic cerebral edema and effect of reperfusion in baboons. J Neurosurg 62:31-41, 1985

*8. Benveniste H: The excitotoxin hypothesis in relation to cerebral ischemia (review). Cerebrovas Brain Metab Rev 3:213-245, 1992

9. Boisseau MR, Dufourcq P, Seigneur M, Roudaut MR, Bertrand A: Changes in cell behaviour during ischaemic cerebrovascular disease. Clin Hemorheol 14:19-25, 1994

10. Carolei A, Fieschi C, Bruno R, Toffano G: Monosialoganglioside GM1 in cerebral ischemia. Cerebrovasc Brain Metab Rev 3:134-157, 1991

11. Cazevieille C, Muller A, Meynier F, Bonne C: Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injury. Free Radical Biol Med 14:389-395, 1993

*12. Cole DJ, Schell RM, Patel PM, Drummond JC, Osborne TN: Brain eicosanoid levels during temporary focal cerebral ischemia in rats: A microdialysis study. J Neurosurg Anesthesiol 5:41-47, 1993

*13. Davalos A, Fernandez-Real JM, Ricart W, Soler S, Molins A, Planas E, Genis D: Iron-related damage in acute ischemic stroke. Stroke 25:1543-1546, 1994

*14. Dawson DA: Nitric oxide and focal cerebral ischemia: Multiplicity of actions and diverse outcome (review). Cerebrovasc Brain Metab Rev 6:299-324, 1994

15. de Courten-Myers GM, Kleinholz M, Wagner KR, Myers RE: Normoglycemia (not hypoglycemia) optimizes outcome from middle cerebral artery occlusion. J Cereb Blood Flow Metab 14:227-236, 1994

16. del Zoppo GJ, Schmid-Schönbein GW, Mori E, Copeland BR, Chang CM: Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22:1276-1283, 1991

17. del Zoppo GJ: Microvascular changes during cerebral ischemia and reperfusion (review). Cerebrovasc Brain Metab Rev 6:47-96, 1994

18. Dell Anna ME, Geloso MC, Draisci G, Luthman J: Transient changes in fos and GFAP immunoreactivity precede neuronal loss in the rat hippocampus following neonatal anoxia. Experimental Neurology 131:144-156, 1995

19. DerouesnE C, Cambon H, Yelnik A, Duyckaerts C, Hauw JJ: Infarcts in the middle cerebral artery territory. Pathological study of the mechanisms of death. Acta Neurol Scand 87:361-366, 1993

20. Folbergrova J, Kiyota Y, Pahlmark K, Memezawa H, Smith ML, Siesjö BK: Does ischemia with reperfusion lead to oxidative damage to proteins in the brain? J Cereb Blood Flow Metab 13:145-152, 1993

21. Folbergrova J, Memezawa H, Smith ML, Siesjö BK: Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. J Cereb Blood Flow Metab 12:25-33, 1992

22. Frerichs KU, Kennedy C, Sokoloff L, Hallenbeck JM: Local cerebral blood flow during hibernation, a model of natural tolerance to "cerebral ischemia". J Cereb Blood Flow Metab 14:193-205, 1994

*23. Funahashi T, Floyd RA, Carney JM: Age effect on brain pH during ischemia/reperfusion and pH influence on peroxidation. Neurobiol Aging 15:161-167, 1994

*24. Garcia JH: The evolution of brain infarcts (review). J Neuropathol Exp Neurol 51:387-393, 1992

25. Gavrilescu T, Kase CS: Clinical stroke syndromes: Clinical-anatomical correlations (review). Cerebrovasc Brain Metab Rev 7:218-239, 1995

*26. Gidday JM, Fitzgibbons JC, Shah AR, Park TS: Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat. Neurosci Lett 168:221-224, 1994

*27. Gill R: The pharmacology of ŕ-amino-3-hydroxy-5methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia (review). Cerebrovasc Brain Metab Rev 6:225-256, 1994

*28. Ginsberg MD: Local metabolic responses to cerebral ischemia (review). Cerebrovasc Brain Metab Rev 2:58-93, 1990

*29 Glazier SS, O'Rourke DM, Graham DI, Welsh FA: Induction of ischemic tolerance following brief focal ischemia in rat brain. J Cereb Blood Flow Metab 14:545-553, 1994

30. Halsey JH Jr., Conger KA, Garcia JH, Sarvary E: The contribution of reoxygenation to ischemic brain damage. J Cereb Blood Flow Metab 11:994-1000, 1991

*31. Hamilton MG, Tranmer BI, Auer RI: Insulin reduction of cerebral infarction due to transient focal ischemia. J Neurosurg 82:262-268, 1995

*32. Heiss WD: Experimental evidence of ischemia thresholds and functional recovery. Stroke 23:1668-1672, 1992

33. Helgason CM: Cardioembolic stroke: Topography and pathogenesis (review). Cerebrovasc Brain Metab Rev 4:28-58, 1993

34. Hornig CR, Bauer T, Simon C, Trittmacher S, Dorndorf W: Hemorrhagic transformation in cardioembolic cerebral infarction. Stroke 24:465-468, 1993

*35. Hossmann K-A. Viability thresholds and the penumbra of focal ischemia (review). Ann Neurol 36:557-565, 1994

*36. Iadecola C, Pelligrino D, Moskowitz MA, Lassen NA: Nitric oxide synthase inhibition and cerebrovascular regulation (review). J Cereb Blood Flow Metab 14:175-192, 1994

37. Johnston WE, Jenkins LW, Lin C-Y, DeWitt DS, Feerick AE, Deyo DJ, Prough DS: Cerebral metabolic consequences of hypotensive challenges in hemodiluted pigs with and without cardiopulmonary bypass. Anesth Analg 81:911-918, 1995

38. Kindy MS, Hu Y, Dempsey RJ: Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. J Cereb Blood Flow Metab 14:1040-1045, 1994

39. Kinouchi H, Sharp FR, Chan PH, Koistinaho J, Sagar SM, Yoshimoto T: Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion. J Cereb Blood Flow Metab 14:808-817, 1994

*40. Klatzo I: Pathophysiological aspects of brain edema (review). Acta Neuropathol 72:236-239, 1987

*41. Kogure K, Kato H: Altered gene expression in cerebral ischemia Stroke 24:2121-2127, 1993

42. Koketsu N, Berlove DJ, Moskowitz MA, Kowall NW, Caday CG, Finklestein SP: Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats. Ann Neurol 35:451-457, 1994

43. Kurokawa Y, Tranmer BI: Interrupted arterial occlusion reduces ischemic damage in a focal cerebral ischemia model of rats. Neurosurgery 37:750-757, 1995

*44. Lehrmann E, Kiefer R, Finsen B, Diemer NH, Zimmer J, Hartung HP: Cytokines in cerebral ischemia: Expression of transforming growth factor Beta-1 (TGF- 1) mRNA in the postischemic adult rat hippocampus. Experimental Neurology 131:114-123, 1995

*45. Li Y, Chopp M, Jiang N, Yao F, Zaloga C: Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397, 1995

46. Linnik MD, Zobrist RH, Hatfield MD: Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2009, 1993

47. Lundgren J, Zhang H, Agardh CD, Smith ML, Evans PJ, Halliwell B, Siesjö BK: Acidosis-induced ischemic brain damage: Are free radicals involved? J Cereb Blood Flow Metab 11:587-596, 1991

48. MacManus JP, Hill IE, Huang ZG, Rasquinha I, Xue D, Buchan AM: DNA damage consistent with apoptosis in transient focal ischaemic neocortex. NeuroReport 5:493-496, 1994

49. McAuley MA: Rodent models of focal ischemia (review). Cerebrovasc Brain Metab Rev 7:153-180, 1995

50. Nakashima K, Todd MM, Warner DS: The relation between cerebral metabolic rate and ischemic depolarization. A comparison of the effects of hypotbermia, pentobarbital, and isoflurane. Anesthesiology 82:1199-1208, 1995

*51. Neumann-Haefelin T, Wieáner C, Vogel P, Back T, Hossmann K-A: Differential expression of the immediate early genes c-fos, c-jun, junB, and NGFI-B in the rat brain following transient forebrain ischemia. J Cereb Blood Flow Metab 14:206-216, 1994

*52. Nishino H, Czurko A, Fukuda A, Hashitani T, Hida H, Karadi Z, Lenard L: Pathophysiological process after transient ischemia of the middle cerebral artery in the rat. Brain Res Bull 35:51-56, 1994

53. Nordborg C, Sokrab TEO, ]ohansson BB: Oedema-related tissue damage after temporary and permanent occlusion of the middle cerebral artery. Neuropathol Appl Neurobiol 20:56-65, 1994

*54. Obrenovitch TP: The ischaemic penumbra: Twenty years on (review). Cerebrovasc Brain Metab Rev 7:297-323, 1995

*55. Obrenovitch TP, Richards DA: Extracellular neurotransmitter changes in cerebral ischaemia (review). Cerebrovasc Brain Metab Rev 7:1-54 , 1995

*56. Paschen W: Polyamine metabolism in reversible cerebral ischemia (review). Cerebrovasc Brain Metab Rev 4:59-88, 1992

*57. Patel PM, Drummond JC, Mitchell MD, Yaksh TL, Cole DJ: Eicosanoid production in the caudate nucleus and dorsal hippocampus after forebrain ischemia: A microdialysis study. J Cereb Blood Flow Metabol 12:88-95, 1992

*58. Patel PM, Drummond JC, Cole DJ, Yaksh TL: Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats. Brain Res 650:205-211, 1994

*59. Pavlakovic G, Eyer CL, Isom GE: Neuroprotective effects of PKC inhibition against chemical hypoxia. Brain Res 676:205-211, 1995

*60. Pearce WJ: Mechanisms of hypoxic cerebral vasodilatation (review). Pharmac Ther 85:75-91, 1995

61. Roine RO, Launes J, Nikkinen P, Phil L, Lindroth L, Kaste M: Regional cerebral blood flow after human cardiac arrest. A hexamethylpropyleneamine oxime single photon emission computed tomographic study. Arch Neurol 48:625-629, 1991

*62. Rothwell NJ, Relton JK: Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage (review). Cerebrovasc Brain Metab Rev 5:178-198, 1993

*63. Rudolphi KA, Schubert P, Parkinson RE, Fredholm, BB: Adenosine and brain ischemia (review). Cerebrovasc Brain Metab Rev 4:346-369, 1992

*64. Sacco RL: Risk factors and outcomes for ischemic stroke. Neurology 45(suppl 1):S10-S14, 1995

*65. Saunders DE, Howe FE, van den Boogaart A, McLean MA, Griffiths JR, Brown MM: Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy. Stroke 26:1007-1013, 1995

66. Schaarschmidt H, Prange HW, Reiber H: Neuron-specific enolase concentrations in blood as a prognostic parameter in cerebrovascular diseases. Stroke 25:558-565, 1994

*67. Schroeter M, Jander S, Witte OW, Stoll G: Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J Neuroimmunol 55:195-203, 1994

68. Selman WR, Bhatti SU, Rosenstein CC, Lust WD, Ratcheson RA: Temporary vessel occlusion in spontaneously hypertensive and normotensive rats. Effect of single and multiple episodes on tissue metabolism and volume of infarction. J Neurosurg 80:1085-1090, 1994

*69. Siesjö BK: Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology (review). J Neurosurg 77:169-184, 1992

*70. Siesjö BK: Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment (review). J Neurosurg 77:337-354, 1992

*71. Steinberg GK, Panahian N, Sun G-H, Maier CM, Kunis D: Cerebral damage caused by interrupted, repeated arterial occlusion versus uninterrupted occlusion in a focal ischemic model. J Neurosurg 81:554-559, 1994

*72. Symon L, Branston NM, Strong AJ: Autoregulation in acute focal ischemia. An experimental study. Stroke 7:547-554, 1976

73. Takagi K, Ginsberg MD, Globus MYT, Dietrich WD, Martinez E, Kraydieh S, Busto R: Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat: Correlation with histopathology. J Cereb Blood Flow Metab 13:575-585, 1993

*74. Tombaugh GC, Sapolsky RM: Evolving concepts about the role of acidosis in ischemic neuropathology (review). J Neurochem 61:793-803, 1993

*75. Traystman RJ, Kirsch JR, Koehler RC: Oxygen radical mechanisms of brain injury following ischemia and reperfusion (review). J Appl Physiol 71:1185:1195, 1991

76. Uchino H, Lundgren J, MD, PhD; Smith M-L, Siesjö BK: Preischemic hyperglycemia leads to delayed postischemic hyperthermia. Stroke 25:1825-1829, 1994

*77. Verhaegen M, Todd MM, Warner DS: Ischemic depolarization during halothane-nitrous oxide and isoflurane-nitrous oxide anesthesia. An examination of cerebral blood flow thresholds and times to depolarization. Anesthesiology 81:965-973, 1994

*78. Verhaegen M, Iaizzo PA, Todd MM: A comparison of the effects of hypothermia, pentobarbital, and isofiurane on cerebral energy stores at the time of ischemic depolarization. Anesthesiology 82:1209-1215, 1995

79. Wang X, Yue T-L, Young PR, Barone FC, Feuerstein GZ: Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex. J Cereb Blood Flow Metab 15:166-171, 1995

80. Wannamethee G, Perry IJ, Shaper AG: Haematocrit, hypertension and risk of stroke. J Intern Med 235:163-168, 1994

*81. Wardlow JM, Dennis MS, Lindley RI, Warlow CP, Sandercock PAG, Sellar R: Does early reperfusion of a cerebral infarct influence cerebral infarct swelling in the acute stage or the final outcome? Cerebrovasc Dis 3:86-93, 1993

82. Wood JH, Dee DB: Hemorheology of the cerebral circulation in stroke (review). Stroke 16:765-772, 1986