Compiled by David S. Warner M.D. and Seiji Takaoka, M.D.
Duke University Medical Center
Copyright (c) 1996 SNACC All Rights Reserved

1. Antognini J: Hypothermia eliminates isoflurane requirements at 20oC. Anesthesiology 78:1152-1156, 1993

2. Antognini J, Lewis B, Reitan J: Hypothermia minimally decreases nitrous oxide anesthetic requirements. Anesth Analg 79:980-982, 1994

3. Astrup J, Skovsted P, Gjerris F, Sorensen H: Increase in extracellular potassium in the brain during circulatory arrest: Effects of hypothermia, lidocaine, and thiopental. Anesthesiology 55:256-262, 1981

4. Aziz L, Ono K, Ohta Y, Morita K, Hirakawa M: Effect of hypothermia on the in vitro potencies of neuromuscular blocking agents and on their antagonism by neostigmine. Brit J Anaesth 73:662-666, 1994

5. Baker A, Zornow M, Grafe M, Scheller M, Skilling S, Smullin D, Larson A: Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits. Stroke 22:666-673, 1991

6. Baker C, Fiore A, Frazzini V, Choudhri T, Zubay G, Solomon R: Intraischemic hypothermia decreases the release of glutamate in the cores of permanent focal cerebral infarcts. Neurosurgery 36:994-1002, 1995

7. Baker C, Onesti S, Solomon R: Reduction by delayed hypothermia of cerebral infarction following middle cerebral artery occlusion in the rat: a time-course study. J Neurosurg 77:438-444, 1992

8. Baker K, Young W, Stone J, Kader A, Baker C, Solomon R: Deliberate mild intraoperative hypothermia for craniotomy. Anesthesiology 81:361-367, 1994

9. Baldwin W, Kirsch J, Hurn P, Toung W, Traystman R: Hypothermic cerebral reperfusion and recovery from ischemia. Am J Physiol 261:H774-H781, 1991

10. Baumgartner W, Silverberg G, Ream A, Jamieson S, Tarabek J, Reitz B: Reappraisal of cardiopulmonary bypass with deep hypothermia and circulatory arrest for complex neurosurgical operations. Surgery 94:242-249, 1983

11. Belopavlovic M, Buchthal A: Cardiac arrest during moderate hypothermia for cerebrovascular surgery. Anaesthesia 35:368-371, 1980

12. Bergstedt K, Hu B, Wieloch T: Postischaemic changes in protein synthesis in the rat brain: Effects of hypothermia. Exp Brain Res 95:91-99, 1993

13. Berntman L, Welsh F, Harp J: Cerebral protective effect of low-grade hypothermia. Anesthesiology 55:495-498, 1981

14. Bickler P, Buck L, Hansen B: Effects of isoflurane and hypothermia on glutamate receptor- mediated calcium influx in brain slices. Anesthesiology 81:1461-1469, 1994

15. Busto R, Dietrich W, Globus M, Ginsberg M: Postichemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett 101:299-304, 1989

16. Busto R, Dietrich W, Globus M, Vald‚s I, Scheinberg P, Ginsberg M: Small differences in intraischemic brain temperature critically determine the extent of neuronal injury. J Cereb Blood Flow Metabol 7:729-738, 1987

17. Busto R, Globus M-T, Dietrich W, Martinez E, Valdes I, Ginsberg M: Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20:904-910, 1989

18. Campkin V: Moderate hypothermia and circulatory arrest for neurosurgical operations. Brit J Anaesth 37:528-532, 1965

19. Cardell M, Boris-Moller F, Wieloch T: Hypothermia prevents the ischemia-induced translocation and inhibition of protein kinase c in the rat striatum. J Neurochem 57:1814-1817, 1991

20. Chaney M: Profound hypothermic circulatory arrest for noncardiac surgery via the closed-chest technique. Anesth Analg 76:892-897, 1993

21. Chen Q, Chopp M, Bodzin G, Chen H: Temperature modulation of cerebral depolarization during focal cerebral ischemia in rats: correlation with ischemic injury. J Cereb Blood Flow Metab 13:389-394, 1993

22. Cheney F, Posner K, Caplan R, Gild W: Burns from warming devices in anesthesia: A closed claims analysis. Anesthesiology 80:806-810, 1994

23. Chyatte D, Elefteriades J, Kim B: Profound hypothermia and circulatory arrest for aneurysm surgery. J Neurosurg 70:489-491, 1989

24. Clifton G, Allen S, Barrodale P, Plenger P, Berry J, Koch S, Fletcher J, Hayes R, Choi S: A phase II study of moderate hypothermia in severe brain injury. J Neurotrauma 10:263-273, 1993

25. Clifton G, Jiang J, Lyeth B, Jenkins L, Hamm R, Hayes R: Marked protection by moderate hypothermia after experimental traumatic brain injury. J Cereb Blood Flow Metab 11:114-121, 1991

26. Coimbra C, Wieloch T: Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia. Acta Neuropathol 87:325- 331, 1994

27. Colbourne F, Corbett D: Delayed postischemic hypothermia: A six month survival study using behavioral and histologic assessments of neuroprotection. J Neurosci 15:7250-7260, 1995

28. Colon R, Frazier O, Cooley D, McAllister H: Hypothermic regional perfusion for protection of the spinal cord during periods of ischemia. Ann Thorac Surg 43:639-643, 1987

29. Dietrich W, Busto R, Alonso O, Globus M, Ginsberg M: Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metabol 13:541-549, 1993

30. Drake C, Barr H, Coles J, Gergely N: The use of extracorporeal circulation and profound hypothermia in the treatment of ruptured intracranial aneurysm. J Neurosurg 21:575-581, 1964

31. Frank S, Beattie C, Christopherson R, Norris E, Perler B, Williams G, Gottlieb S: Unintentional hypothermia is associated with postoperative myocardial ischemia. Anesthesiology 78:468- 476, 1993

32. Frank S, Higgins M, Breslow M, Fleisher L, Gorman R, Sitzmann J, Raff H, Beattie C: The catecholamine, cortisol, and hemodynamic responses to mild perioperative hypothermia: A randomized clinical trial. Anesthesiology 82:83-93, 1995

33. Globus M, Alonso O, Dietrich W, Busto R, Ginsberg M: Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia. J Neurochem 65:1704-1711, 1995

34. Globus M, Busto R, Lin B, Schnippering H, Ginsberg M: Detection of free radical activity during transient global ischemia and recirculation: Effects of intraischemic brain temperature modulation. J Neurochem 65:1250-1256, 1995

35. Heier T, Caldwell J, Sessler D, Miller R: Mild intraoperative hypothermia increases duration of action and spontaneous recovery of vecuronium blockade during nitrous oxide-isoflurane anesthesia in humans. Anesthesiology 74:815-819, 1991

36. Hu B, Kamme F, Wieloch T: Alterations of Ca2+/calmodulin-dependent protein kinase II and its messenger RNA in the rat hippocampus following normo- and hypothermic ischemia. Neuroscience 68:1003-1016, 1995

37. Illievich U, Spiss C: Hypothermic therapy for the injured brain. Curr Opin Anaesth 7:394-400, 1994

38. Kader A, Frazzini V, Baker C, Solomon R, Trifiletti R: Effect of mild hypothermia on nitric oxide synthesis during focal cerebral ischemia. Neurosurgery 35:272-277, 1994

39. Karibe H, Chen S, Zarow G, Gafni J, Graham S, Chan P, Weinstein P: Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats. Brain Res 649:12-18, 1994

40. Katsura K, Minamisawa H, Ekholm A, Folbergrova J, Siesj” B: Changes of labile metabolites during anoxia in moderately hypo- and hyperthermic rats: correlation to membrane fluxes of K+. Brain Res 590:6-12, 1992

41. Koht A, Cane R, Cerullo L: Serum potassium levels during prolonged hypothermia. Intensive Care Med 9:275-277, 1983

42. Laptook A, Corbett R, Burns D, Sterett R: Neonatal ischemic neuroprotection by modest hypothermia is associated with attenuated brain acidosis. Stroke 26:1240-1246, 1995

43. Leslie K, Sessler D, Bjorksten A, Moayeri A: Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg 80:1007-1014, 1995

44. Levy W: Quantitative analysis of EEG changes during hypothermia. Anesthesiology 60:291-297, 1984

45. Lundgren J, Smith M-L, Blennow G, Siesj” B: Hyperthermia aggravates and hypothermia ameliorates epileptic brain damage. Exp Brain Res 99:43-55, 1994

46. Marion D, Obrist W, Carlier P, Penrod L, Darby J: The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report. J Neurosurg 79:354-362, 1993

47. Mellerg†rd P: Changes in human intracerebral temperature in response to different methods of brain cooling. Neurosurgery 31:671-677, 1992

48. Michenfelder J, Milde J: Failure of prolonged hypocapnia, hypothermia, or hypertension to favorably alter acute stroke in primates. Stroke 8:87-91, 1977

49. Michenfelder J, Milde J: The relationship among canine brain temperature, metabolism, and function during hypothermia. Anesthesiology 75:130-136, 1991

50. Michenfelder J, Uihlein A, Daw E, Theye R: Moderate hypothermia in man: haemodynamic and metabolic effects. Br J Anaesth 37:738-745, 1965

51. Nakashima K, Todd M, Warner D: The relation between cerebral metabolic rate and ischemic depoliarization: A comparison of the effects of hypothermia, pentobarbital, and isoflurane. Anesthesiology 82:1199-1208, 1995

52. Rand P, Lacombe E, Hunt H, Austin W: Viscosity of normal human blood under normothermic and hypothermic conditions. J Appl Physiol 19:117-122, 1964

53. Resnick D, Marion D, Darby J: The effect of hypothermia on the incidence of delayed traumatic intracerebral hemorrhage. Neurosurgery 34:252-256, 1994

54. Ridenour T, Warner D, Todd M, McAllister A: Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in the rat. Stroke 23:733-738, 1992

55. Rosomoff H: Protective effects of hypothermia against pathological processes of the nervous system. Ann NY Acad Sci 80:475-486, 1959

56. Sano T, Drummond J, Patel P, Grafe M, Watson J, Cole D: A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat. Anesthesiology 76:221-228, 1992

57. Sheffield C, Sessler D, Hunt T: Mild hypothermia during isoflurane anesthesia decreases resistance to E. coli dermal infection in guinea pigs. Acta Anaesthesiol Scand 38:201-205, 1994

58. Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, Sugimoto T: Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 79:363-368, 1993

59. Silverberg G, Reitz B, Ream A: Hypothermia and cardiac arrest in the treatment of giant aneurysms of the cerebral circulation and hemangioblastoma of the medulla. J Neurosurg 55:337-346, 1981

60. Solomon R, Smith C, Raps E, Young W, Stone J, Fink M: Deep hypothermic circulatory arrest for the management of complex anterior and posterior circulation aneurysms. Neurosurgery 29:732-738, 1991

61. Steen P, Soule E, Michenfelder J: Detrimental effect of prolonged hypothermia in cats and monkeys with and without regional cerebral ischemia. Stroke 10:522-529, 1979

62. Stone J, Young W, Smith C, Solomon R, Wald A, Ostapkovich N, Shrebnick D: Do standard monitoring sites reflect true brain temperature when profound hypothermia is rapidly induced and reversed? Anesthesiology 82:344-351, 1995

63. Thomas A, Anderton J, Harper N: Anaesthesia for the treatment of a giant cerebral aneurysm under hypothermic circulatory arrest. Anaesthesia 45:383-385, 1990

64. Trevino A, Razi B, Beller B: The characteristic electrocardiogram of accidental hypothermia. Arch Intern Med 127:470-473, 1971

65. Verhaegen M, Iaizzo P, Todd M: A comparison of the effects of hypothermia, pentobarbital, and isoflurane on cerebral energy stores at the time of ischemic depolarization. Anesthesiology 82:1209-1215, 1995

66. Wass C, Lanier W, Hofer R, Scheithauer B, Andrews A: Temperature changes of > 1 oC alter functional neurologic outcome and histopathology in a canine model of complete cerebral ischemia. Anesthesiology 83:325-335, 1995

67. Weinrauch V, Safar P, Tisherman S, Kuboyama K, Radovsky A: Beneficial effect of mild hypothermia and detrimental effect of deep hypothermia after cardiac arrest in dogs. Stroke 23:1454-1461, 1992

68. Widmann R, Miyazawa T, Hossmann K: Protective effect of hypothermia on hippocampal injury after 30 minutes of forebrain ischemia in rats is mediated by postischemic recovery of protein synthesis. J Neurochem 61:200-209, 1993

69. Wong K: Physiology and pharmacology of hypothermia. Western J Med 138:227-232, 1983